Imaging Measures Predict Progression in Progressive Supranuclear Palsy
Identifieur interne : 001096 ( Main/Exploration ); précédent : 001095; suivant : 001097Imaging Measures Predict Progression in Progressive Supranuclear Palsy
Auteurs : Jennifer L. Whitwell [États-Unis] ; JIA XU [États-Unis] ; Jay Mandrekar [États-Unis] ; Jeffrey L. Gunter [États-Unis] ; Clifford R. Jr Jack [États-Unis] ; Keith A. Josephs [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Objective: The aim of this work was to determine whether the progressive supranuclear palsy rating scale, a measure of disease severity, is associated with neuroanatomical changes in progressive supranuclear palsy. Methods: We recruited 22 subjects with probable progressive supranuclear palsy who completed the progressive supranuclear palsy rating scale at 2 time points. All subjects had magnetic resonance imaging and diffusion tensor imaging. Associations were assessed between whole brain volume, ventricular volume, midbrain area and superior cerebellar peduncle fractional anisotropy, and baseline/change of the progressive supranuclear palsy rating scale. Results: Superior cerebellar peduncle fractional anisotropy correlated with the total score and gait/midline subscore of the progressive supranuclear palsy rating scale. Whole brain volume, midbrain area, and disease duration predicted subsequent change over time in the gait/midline subscore of the progressive supranuclear palsy rating scale. Conclusions: Imaging measures could be useful to help predict clinical progression in subjects with progressive supranuclear palsy.
Affiliations:
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Whitwell</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Jia Xu" sort="Jia Xu" uniqKey="Jia Xu" last="Jia Xu">JIA XU</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Health Science Research (Biostatistics), Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Mandrekar, Jay" sort="Mandrekar, Jay" uniqKey="Mandrekar J" first="Jay" last="Mandrekar">Jay Mandrekar</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Health Science Research (Biostatistics), Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gunter, Jeffrey L" sort="Gunter, Jeffrey L" uniqKey="Gunter J" first="Jeffrey L." last="Gunter">Jeffrey L. 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Whitwell</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Jia Xu" sort="Jia Xu" uniqKey="Jia Xu" last="Jia Xu">JIA XU</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Health Science Research (Biostatistics), Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Mandrekar, Jay" sort="Mandrekar, Jay" uniqKey="Mandrekar J" first="Jay" last="Mandrekar">Jay Mandrekar</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Health Science Research (Biostatistics), Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gunter, Jeffrey L" sort="Gunter, Jeffrey L" uniqKey="Gunter J" first="Jeffrey L." last="Gunter">Jeffrey L. Gunter</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Information Technology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellar peduncle</term><term>Diffusion tensor imaging</term><term>Evaluation scale</term><term>Midbrain</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Supranuclear ophthalmoplegia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Ophtalmoplégie supranucléaire</term><term>Echelle d'évaluation</term><term>Imagerie RMN</term><term>Imagerie du tenseur de diffusion</term><term>Mésencéphale</term><term>Pédoncule cérébelleux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: The aim of this work was to determine whether the progressive supranuclear palsy rating scale, a measure of disease severity, is associated with neuroanatomical changes in progressive supranuclear palsy. Methods: We recruited 22 subjects with probable progressive supranuclear palsy who completed the progressive supranuclear palsy rating scale at 2 time points. All subjects had magnetic resonance imaging and diffusion tensor imaging. Associations were assessed between whole brain volume, ventricular volume, midbrain area and superior cerebellar peduncle fractional anisotropy, and baseline/change of the progressive supranuclear palsy rating scale. Results: Superior cerebellar peduncle fractional anisotropy correlated with the total score and gait/midline subscore of the progressive supranuclear palsy rating scale. Whole brain volume, midbrain area, and disease duration predicted subsequent change over time in the gait/midline subscore of the progressive supranuclear palsy rating scale. Conclusions: Imaging measures could be useful to help predict clinical progression in subjects with progressive supranuclear palsy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L." last="Whitwell">Jennifer L. Whitwell</name></region><name sortKey="Gunter, Jeffrey L" sort="Gunter, Jeffrey L" uniqKey="Gunter J" first="Jeffrey L." last="Gunter">Jeffrey L. Gunter</name><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name><name sortKey="Jia Xu" sort="Jia Xu" uniqKey="Jia Xu" last="Jia Xu">JIA XU</name><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name><name sortKey="Mandrekar, Jay" sort="Mandrekar, Jay" uniqKey="Mandrekar J" first="Jay" last="Mandrekar">Jay Mandrekar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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